Sorry if this has been mentioned previously, but I've only ever had the -2 billion bug once. In 1.26, I started rolling out drugs to the girls, which was the first time to do so on a rather large scale, and soon after I had the game ending bug. I had just saved before I hit the Next Week button, and although I did a few things differently, it always happened.
I also have 100% crashes in the opponent has come to you third choice, in 1.29. I can cast him out on the streets fine, but whenever I try to smuggle him out, crash. The summary never had the customer has daughters event, and I didn't try to kill him, that might work fine. I did do a few reloads to test this out.