Technically i found Whoremaster simply faster and you quickly start getting lots of "employees".
Gameplaywise the game is also more focused on the business side, while Pytfall focuses more on the main character and his "adventures".
You can do a lot of similar things and will find similarities in both, probably because pytfall was started as a renpy mod to whoremaster (afaik).
Also i think both are still open-ended without a "win game" clause?
