Is it the torturer crash? I played for a long time without having it happen, then one day it just started on me. If unfamiliar with it, when the matron tries to take the torturer off shift to rest it crashes the game. I heal the torturer or take her off myself to solve it. That's the only crash issue I've had (that I didn't cause myself.) If that's not the issue, try taking matrons off duty before hitting next week to see if it's a similar issue.