I regularly get crashes when I go to the slave market, see a specific girl ect (Basically random screens) after I load some of my games, It usually resolves itself after I restart the game, sometimes it takes 2-4 times. Also yeah, save your save games! Copy all or just the specific save (remember to get the .mast file and .sav file!) and put them somewhere else you'll remember them.
If it still consistently screws up, IDK, but yeah like iamnuff stated, script triggers shouldn't be causing the crash as only 3 girls have scripts. (wish there was more!)
I haven't had a NEXT WEEK crash since 1.30 came out though, and I have 3gigs of girls and random item lists in my games. Maybe someone else can help you out.
I also get a crash on exit 70% of the time, but it never effects my saves so IDK what that is about either. I wonder what happened to the threesome option (and others in the talk menu) and the movie jobs. Are they completely out of the picture now?