On the other hand, I could see some mileage though in a campaign where the task was to constantly keep shoring up Mundiga's metaphysical underpinnings. "OK, so what's about to destroy the universe this week?"
You know, I think that would be
AWESOME. Like a passive thing going on that is visible and gives you a bonus to something, like +10% probability of running into constructs this week because a dimension to an undead robot race (lolnecron) has been opened up.
Maybe you can have access to a mage council that you can attempt to influence to keep that setting for another week. Maybe sacrifice girls, or donate money to them for a chance at this. These anomalies could last several weeks at a time, or only one... Maybe have several different kinds, with week long extremes being uncommon and then have month long ones...
Some of the extremes will be like +10% customers/tips for a week due to exotic traders coming in through another dimension.
+5% chance of tentacle raep due to Cthulhu invading.... things like that. Perhaps the "month long" ones could be like 5% less injuries or tiredness from alien medicine, or even a moon phasing into existence that shined a healing light. If there were negative effects, I wouldn't make them devastating, and I wouldn't make too many positive ones either. Mostly just "different" occurrences to give the world a more interesting approach.
Perhaps there would be a 15% chance of an extreme event happening for a week, 25% chance of a "Different but not better/worse" event happening for a week, ect.
Some of the "different but not better/worse" ones could be like mostly finding girls that are small chested or have strange eyes for that week, maybe one week could be girls with more mana then others... things like that.
Of course i'm just talking out my ass since I let my imagination get me carried away... but I do think it would be cool.