not going into the Research and Development thing are we? R&D for the purpose of sexual gratification does lend a different perspective. *ponders which machines and what techniques* not to mention research assistants and *guinea pigs*
Oooh, now. Don't tempt me

I have a half written flash game somewhere called Mad Science 101 which is heavily based around those themes. One of these days I'll get back to it...
But yeah, I want most of these facilities to start locked and to need some event or activity to unlock them. I'm not sure a research tree fits all that well, but I'd like to do something like that.